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KMID : 0370219870310030154
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Yakhak Hoeji
1987 Volume.31 No. 3 p.154 ~ p.163
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Studies on the anti-inflammatory activity and its mechanism of daidzein
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허인회/Huh IH
이상준/김형춘/Lee SJ/Kim HC
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Abstract
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Daidzein and its methyl derivatives were synthesized and their anti-inflammatory activities were examined. Daidzein suppressed the carrageenin-induced edema, but its methyl derivatives showed decrease or abolition of the anti-inflammatory effect. Daidzein did not significantly suppress the complete Freund’’s adjuvant-induced arthritis, and the mixed phlogistics (histamine + serotonin)-induced edema. Daidzein inhibited the leukocyte emigration and protein exudation when it was administered into the CMC pouch at low doses (5.25mg/pouch). Daidzein significantly suppressed the cotton-pellet granuloma formation.
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FullTexts / Linksout information
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